Grading Breast Cancer Tissues Using Molecular Portraits
نویسندگان
چکیده
منابع مشابه
Grading Breast Cancer Tissues Using Molecular Portraits*
Tumor progression and prognosis in breast cancer patients are difficult to assess using current clinical and laboratory parameters, where a pathological grading is indicative of tumor aggressiveness. This grading is based on assessments of nuclear grade, tubule formation, and mitotic rate. We report here the first protein signatures associated with histological grades of breast cancer, determin...
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Breast cancer is a heterogeneous disease in terms of histology, therapeutic response, dissemination patterns to distant sites, and patient outcomes. Global gene expression analyses using high-throughput technologies have helped to explain much of this heterogeneity and provided important new classifications of cancer patients. In the last decade, genomic studies have established five breast can...
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Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3, and FOXA1 as ILC enriched features. PTEN loss associated with increas...
متن کاملMethod for grading breast cancer.
labelling.' PCNA immunohistochemical expression (evaluated with the PCI0 mono-clonal antibody) seems to be related to cellular proliferation in many normal tissues and in some neoplasms,2 such as gastro-intestinal lymphomas,3 central nervous system tumours,4 lung neuroendocrine neoplasms,' and prostatic carcinomas.' However, in other tumours, like breast and gastric cancer, PCNA (PC 10) express...
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The risk of distant recurrence in breast cancer patients is difficult to assess with current clinical and histopathological parameters, and no validated serum biomarkers currently exist. Using a recently developed recombinant antibody microarray platform containing 135 antibodies against 65 mainly immunoregulatory proteins, we screened 240 sera from 64 patients with primary breast cancer. This ...
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2013
ISSN: 1535-9476
DOI: 10.1074/mcp.m113.030379